Metastatic cutaneous Crohn’s disease as an important differential diagnosis of granulomatous skin disease

Psychiatric onset Alexander disease: an important challenge in neuropsychiatric diagnosis

Introduction: Alexander disease is a heterogenous group of diseases with various manifestations based on age of disease onset. This rare leukodystrophy syndrome with mutations in GFAP Gene could present with developmental delay and seizure in infantile form to ataxia and bulbar palsy in adulthood. However psychiatric symptoms are not well-defined and usually evaluate after disease diagnosis not...

Granulomatous lung disease: an approach to the differential diagnosis.

CONTEXT Granulomas are among the most commonly encountered abnormalities in pulmonary pathology and often pose a diagnostic challenge. Although most pathologists are aware of the need to exclude an infection in this setting, there is less familiarity with the specific histologic features that aid in the differential diagnosis. OBJECTIVE To review the differential diagnosis, suggest a practica...

Moyamoya disease. An important differential diagnosis to cerebral vasculitis

Methods A three-year-old girl, with a former history of Kawasaki disease, presented with a stroke. Both parents were of Korean heritage. Stenosis of the middle cerebral artery on both sides was seen on MR angiogram. No abnormal blood tests were found. Treatment of suspected cerebral vasculitis was initiated with steroids orally (2mg/kg/d). She developed recurrent transient ischemic attacks in b...

Diagnosis of Chronic Granulomatous Disease

Cutaneous Rosai-Dorfman disease: an uncommon cause of granulomatous inflammation

Yau Ma Tei Dermatology Clinic, 12/F, Yau Ma Tei Specialist Clinic, 143 Battery Street, Kowloon, Hong Kong Rosai-Dorfman disease (RDD) is a benign idiopathic proliferative disorder. It commonly affects lymph nodes, but other organs can be involved. RDD limited to skin is rare. We report a 45-yearold Chinese man suffering from RDD. The first three skin biopsies revealed granulomatous inflammation...